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Tumour-loving bugs deliver killer blow

 

NewScientist.com news service

James Randerson, Edinburgh

 

A humble and harmless soil bacterium is the latest recruit in the war on cancer. The bug is known to grow only inside tumours when it infects humans and has now been given a lethal new trick.

 

Researchers genetically engineered Clostridium bacteria so they were able to convert a harmless chemical into a potent toxin. Injecting the chemical into the patient's bloodstream should therefore destroy tumours from the inside, while leaving healthy tissues unharmed.

 

The idea of converting a harmless "prodrug" into a substance that kills cells only in a tumour is not new. "But the field has taken one step forward and one step back," says Nigel Minton at the University of Nottingham, UK.

 

One approach has been to attach the enzyme that converts the prodrug into the toxin to an antibody that binds only to cancer cells. But different tumour types require different antibodies, making it expensive to develop. Minton and his team hope their bacterial approach will offer a way of delivering the enzymes to any cancer cell.

 

Tightly packed cells

The idea that bacteria could be used as a cancer therapy originated over 100 years ago, when physician William Coley noticed some of his patients with bacterial infections were able to fight off cancer. Later work showed that Clostridium bacteria grew happily in cancerous tissue because they thrive in low oxygen conditions. The tightly packed cells and poor blood supply of a tumour make it ideal.

 

But attempts to use the bacteria as a treatment were disappointing. The bugs made an impressive initial onslaught on tumours in animal experiments, but a ring of cancerous tissue around the edge usually survived and went on to rejuvenate the tumour.

 

Now Minton is combining this technique with the prodrug method. He has engineered a harmless strain of Clostridium to carry an extra loop of DNA that contains the gene for the enzyme that converts the prodrug. Importantly, the bacteria deliver the enzyme to any tumour, he told the Society for General Microbiology's spring meeting in Edinburgh.

 

One initial fear was that the bacteria might find their way into other low oxygen parts of the body such as the gut. But this did not happen in tests on mice.

 

Another issue is whether small tumours will have too much oxygen for the bugs to survive. "It is difficult to say how large a tumour will have to be for the technique to work," says team member Philip Burke at Enact Pharma, near Salisbury. But he hopes that planned clinical trials in patients should provide an answer

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"Nobody shoots anybody in the face unless you're a hit man or a video gamer," Thompson told the paper.

 

wow, id normally be annoyed by ignorance like that, but its hard to put my feelings into words, i just want to shoot this Thompson fuck in the face so very bac.

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heh

 

so yeah, the new chick who seems to be working my apartment's gym, she's playing some other spanish music, mebbe merenge or something, instead of reaggeton, so i like her already.

thing is, she sees me there at the hour i go, there's not many guys and my gringo ass stands out, so i think she feels compelled to play some stereotypical whiteboy shit, so next thing i know the track's cut and its "welcome to the jungle" or something, and i swear she looks over to see if im more comfortable or something.

 

I dont go for the motiviational shit; im already at the gym, im not one of the faggots who needs to hear eye of the fucking tiger to finish a set. Just play something that doesnt suck...if youre gonna loop Use your Illusion, at least get to Civil War or something like that before im done.

 

and id tell her that, but she doesnt speak much english, and my spanish is still weak at best. But this is miami, so these moments get overshadowed by spanish cuisine and, you know, nica chicks.

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tire blew out on the truck at almost the same time my cellphone died, that was pretty funny.

this truck keeps limping along, and i keep hoping its not much more to go, but i really am kinda playing it right on the line these last few years.

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B000084T2V.01._SS500_SCLZZZZZZZ_.jpg

 

The High Party

 

I'm looking at another day to find that I've got nothing to say,

or I'm looking for another way to process what happened on that birthday,

and either way, if you're gonna call it art, then there's a cup in front of you

and right away, if you're gonna play your part, you must drink it down, drink it down.

 

But mine eyes have seen the glory of the fields of flowers and factory floors,

and my mind's content to lie at rest for hours behind my loved ones' doors

and if there's a war, another shitty war to fight for Babylon,

then it's the perfect storm in a tea cup, but you must drink it down, drink it down, drink it down, drink it down.

 

And what do you make of nights when you thought you'd make much more

than being too tired to turn the lights out and too tired to drink more?

And what does it take to not hear the cynics at your door

saying "Its time to turn the lights out, and you'll want to keep it down, keep it down, keep it down, keep it down!"

 

So I'm lifting up that poison cup to drink a draught of propaganda,

or I'm giving up that other stuff in hopes that it's gonna make me madder.

But either way, if you're gonna call it art, then there's a cup in front of you

and right away, if you're gonna play your part, you must drink it down, drink it down, drink it down, drink it down.

 

And what do you make of nights when you thought you'd make much more

than being too tired to turn the lights out and too tired to drink more?

And what does it take to not hear the cynics at your door

saying "It's time to turn the lights out, and you'll want to keep it down, keep it down, keep it down, keep it down!"

 

And what do you make of nights when you thought you'd make much more

than being too drunk to turn the lights out and too tired to drink more?

And what does it take to not hear the cynics at your door

saying "It's time to turn the lights out, and you'll want to keep it!"

 

Pull-2-3-4! Pull-2-3-4!...

 

And what does it say of all the things you've said before,

when you're too tired to turn the lights out and too drunk to drink more?

And what do you save? And what does it feel like to be saved?

And can you "Pull-2-3-4! Pull-2-3!"

Can you drink it down?

Can you drink it down?

Can you drink it down?

Can you drink it down?

Can you drink it down?

Can you drink it down?

Can you drink it down?

Can you drink it down?

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I walked outside in my socks and tiptoed between shards of broken glass to get to the ice cream truck I heard passing by the house. I paid a with a pile of five penny coins.

 

I feel like a kid again. Not me as a kid, happier.

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