Alrighty. As for comedy, I have:
Tales From the Floating Vagabond
My personal favorite, this game can have nearly any character from nearly any universe, and has great skills like "swing nasty pointy things" and "stabbing fleshy things that scream and die" and "Look Good at All Times."Classic.
DnD
A more serious game, and I do stress more, as it can still be sorta slapstick silly.Involves being elves and dwarves, wizards and fighters, etc. Lots of killin things and takin their stuff so as to go kill other things.
RISUS
Called the 'anything RPG' this game consists of writing two or three things on a post-it note and starting the game. Very free form, not a lot of character statistical development, but only as much depth as you put in to it, as there is none by default.
Can-d6
Invented by a friend of mine, this game requires a bowl of wrapped candies to play. (Wrapped candies are needed as the candy changes hands several times before you eat it.) Everyone plays a 6 year old. The first game of this I ever ran was for Halloween, and the characters were Trick-or-Treating, and discovered a ghost or some such. Everyone loves acting 6 years old, so its fun!
Spirit of the Century
A simple to play, Indiana Jones style pulp game, with rewards for entertaining the group and doing things that are awesome, rather than knowing all the rules and making tactical decisions.
Big Eyes, Small Mouth
An anime game (thus the name) which incorporates nearly any setting and style. This could be played as a 'lets be in the Pokemon universe' as easily as 'lets play Gundam' so it fits whatever we want to do. Lots of action, simple system to learn and play.
Also, if any of you Hondonian's have comments on the games above, they are more than welcome, wheather you are wanting to able to play or not. Feel free to tell me I am dumb, or that we should play your game instead, whatever.